This paper-based interactive karyotype activity allows you to simulate a clinical genetics lab. You will act as a cytogeneticist to organize chromosomes and diagnose a chromosomal disorder.
These conditions involve an abnormal count of the X or Y sex chromosomes, often presenting milder symptoms than autosomal trisomies.
: Connects classroom biology to real-world medical diagnostics. Interactive Karyotype Activity
: The constricted region (centromere) can be in the middle (metacentric), off-center (submetacentric), or near the very end (acrocentric).
function updateDiagnosisMessage() []; let sexTypes = sexChromosomes.map(id => chromosomes.find(c => c.id === id)?.type); let sexCount = sexChromosomes.length; for (let i=1; i<=22; i++) const slotLen = karyoSlots[i].length; if (slotLen === 2) filledPairs++; if (slotLen > 2) filledPairs = -999; : Provide a printed sheet of "mixed" chromosomes,
Students match chromosomes based on size, centromere position, and distinct banding patterns.
: Provide a printed sheet of "mixed" chromosomes, scissors, and a template for manual arrangement. let sexTypes = sexChromosomes.map(id =>
: Utilizing web-based simulations or slide software (like Google Slides), students click and move digital images of chromosomes into their correct positions. Key Attributes for Matching